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Face Serum + Moisturizer

Longevity Protocol - 40mL

Clinically + Dermatologist Tested

45 day satisfaction guarantee + FREE shipping

Daily, all-in-one face and neck cream that minimizes existing visible aging and delays future signs. Powered by L-01™ , growth factor peptides proven to reverse aging markers. Designed by biologists, formulated by chemists. 

ships in 1 business day, FREE on every order
Benefits

Minimize existing visible aging + defend against future signs

  • Skin Barrier — strengthens + repairs barrier for skin defense
  • Elasticity & structure — supports collagen and elastin for visibly firmer skin
  • Fine lines & wrinkles — 2X more effective than retinol at reducing the appearance of wrinkle depth*
  • Uneven tone & dullness — evens tone and restores radiance
  • Texture — smooths and refines for a softer surface
  • Visibly targets expression lines by increasing skin's resilience: crows feet, nasolabial folds, frown lines etc.

*Head to head clinical study with 0.3% Retinol

Clean + Safe Ingredients

Ingredient Spotlight

(at clinically validated concentrations)

  • 3.5% L‑01™ - biomimetic grow factor peptides (EGF, FGF, IGF), and NAD+ support complex, plus ubiquinone antioxidant.
  • 5% Niacinamide - Vitamin B3 that is essential for cellular energy and metabolism
  • 10+% Squalane + Propanediol - biomimetic moisture duo for barrier support and deep hydration

Full List:

Water, Squalane, Glycerin, Propanediol, Niacinamide, Maltodextrin, Phenoxyethanol, Polyglyceryl-2 Stearate, Glyceryl Stearate, Stearyl Alcohol, Vitamin E, Hydroxyethyl Acrylate, Ethylhexylglycerin, Tetrasodium Glutamate Diacetate, Xanthan Gum, Gluconolactone, Sorbitan Isostearate, Sodium Benzoate, L‑01™ Peptide Complex, Radish Root Ferment, Oligopeptide-2, Hyaluronic Acid, Sunflower Sprout Extract, Phospholipids, CoQ10.

Face Serum + Moisturizer
Face Serum + Moisturizer
Sale price$93.00
Dermatologist Tested
Fragrance free
Sensitive skin safe

Trusted by Experts

Dr. Jen Haley

"A well-researched approach to supporting skin barrier function and improving the appearance of visible aging."

Dr. Jen HaleyBoard-certified Dermatologist
DR. Sam Chatterjee

"the Longevity Protocol Serum + Moisturizer is more than just a multitasking product; it represents a new standard in skincare efficiency."

DR. Sam ChatterjeeBoard-certified Dermatologist

Developed with Research from

POWERED BY L-01™

Stem cell peptides built for skin longevity.*

Plant-derived growth factor peptides modeled on the body's own signaling proteins for repair, paired with an NAD+ precursor to energize skin

(biomimetic EGF, FGF-2, IGF-1)

Read the science →
78.4%
More collagen + Elastin*
46.8%
decrease in skin cell aging*
36.1%
reduced inflammation markers
10×
more stable than other peptides*
[Collagen I] in untreated cells
[Collagen I] after L-01™: +61%
[Inflammation marker] in untreated cells
[Inflammation marker] after L-01™: -47%

* Based on L-01 in-vitro data on human skin cell models and/or clinical tests. Read more at darkfinlabs.com/pages/about-us.

Dropping my 7-step routine
Dropping my 7-step routine
@mayaglow
Game-changing skincare routine
Game-changing skincare routine
@katiemumford
Favorite new product
Favorite new product
@allison
Beautiful skin in my 50s
Beautiful skin in my 50s
jessicaskin
Morning routine, simplified
Morning routine, simplified
@katherineee
reversing skin's age
reversing skin's age
@annalinie
Biohacking GRWM
Biohacking GRWM
@katiemumford
★★★★★

""This is an incredible product that has done wonders for my dehydrated skin and fine lines. I started recommending it to my clients, and they fell in love as well!""

— Maya Stuart, 36, Aesthetician

Visible CHANGE

DAILY AM + PM USE

BEFORE
AFTER
EYE WRINKLES
Fine lines and crow's feet
Subject A
before
After
REDNESS + BLEMISH
Even tone and calm skin
Subject C

Individual results may vary.

Key Ingredients

Precision Repair + Defense Biosystem

L-01™

Niacinamide

Tocopherol (Vitamin E)

Ubiquinone (Coenzyme Q10)

Glycerin

Squalane

Propanediol

Leuconostoc/Radish Root Ferment Filtrate

Full Ingredient List

Darkfin Labs

Proprietary complex made of encapsulated EGF, FGF-2, and IGF-1 alongside powerful NAD+ precursor complex. It mimics young skin's natural signaling peptides for repair and enhanced skin vitality.

Darkfin Labs

Multi-functional active that brightens, strengthens the barrier, calms inflammation, and improves texture.

Darkfin Labs

Antioxidant that helps protect the skin from oxidative damage and ROS accumulation

Darkfin Labs

Potent antioxidant that protects against oxidative stress and helps support skin’s natural energy production and repair.

Darkfin Labs

Humectant that pulls water into the skin for deep, long-lasting hydration.

Darkfin Labs

Lightweight emollient that restores suppleness and strengthens the lipid barrier without feeling greasy.

Darkfin Labs

Plant-derived humectant and penetration enhancer that boosts absorption and gives a smoother skin feel.

Darkfin Labs

A natural preservative derived from radish root fermentation that provides antimicrobial protection while also offering light hydration and skin-soothing benefits

Water (Aqua), Squalane, Glycerin, Propanediol, Niacinamide, Ethylhexylglycerin, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Polyglyceryl-2 Stearate, Sorbitan Isostearate, Stearyl Alcohol, Tetrasodium Glutamate Diacetate, Tocopherol, Camelina Sativa Oleosomes/Camelina Sativa sr-(Arabidopsis Thaliana Polypeptide-2 sh-Oligopeptide-1), Gluconolactone, Helianthus Annuus (Sunflower) Sprout Extract, Leuconostoc/Radish Root Ferment Filtrate, Maltodextrin, Oligopeptide-1, Oligopeptide-2, Phospholipids, sh-Polypeptide-1, Sodium Benzoate, Sodium Hyaluronate, Ubiquinone, Xanthan Gum.

L-01™

Proprietary complex made of encapsulated EGF, FGF-2, and IGF-1 alongside powerful NAD+ precursor complex. It mimics young skin's natural signaling peptides for repair and enhanced skin vitality.

Darkfin Labs

Niacinamide

Multi-functional active that brightens, strengthens the barrier, calms inflammation, and improves texture.

Darkfin Labs

Tocopherol (Vitamin E)

Antioxidant that helps protect the skin from oxidative damage and ROS accumulation

Darkfin Labs

Ubiquinone (Coenzyme Q10)

Potent antioxidant that protects against oxidative stress and helps support skin’s natural energy production and repair.

Darkfin Labs

Glycerin

Humectant that pulls water into the skin for deep, long-lasting hydration.

Darkfin Labs

Squalane

Lightweight emollient that restores suppleness and strengthens the lipid barrier without feeling greasy.

Darkfin Labs

Propanediol

Plant-derived humectant and penetration enhancer that boosts absorption and gives a smoother skin feel.

Darkfin Labs

Leuconostoc/Radish Root Ferment Filtrate

A natural preservative derived from radish root fermentation that provides antimicrobial protection while also offering light hydration and skin-soothing benefits

Darkfin Labs

Full Ingredient List

Water (Aqua), Squalane, Glycerin, Propanediol, Niacinamide, Ethylhexylglycerin, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Polyglyceryl-2 Stearate, Sorbitan Isostearate, Stearyl Alcohol, Tetrasodium Glutamate Diacetate, Tocopherol, Camelina Sativa Oleosomes/Camelina Sativa sr-(Arabidopsis Thaliana Polypeptide-2 sh-Oligopeptide-1), Gluconolactone, Helianthus Annuus (Sunflower) Sprout Extract, Leuconostoc/Radish Root Ferment Filtrate, Maltodextrin, Oligopeptide-1, Oligopeptide-2, Phospholipids, sh-Polypeptide-1, Sodium Benzoate, Sodium Hyaluronate, Ubiquinone, Xanthan Gum.

What it does.

Reverse visible skin aging
significantly reduced visible aging even after UV or environmental stress
Reduce expression lines
Targets crows feet, nasolabial folds, forehead lines
visibly Restores elasticity
Supports skin's youthful epidermal structure
Refines texture + discorloration
smooth and glowing complexion

* Action on skin appearance. Based on in-vitro and clinical testing on formulation and ingredients.

One step. AM + PM.

1
Cleanse.Start with clean, dry skin.
2
Apply.2–3 drops over face and neck.
3
SPF (AM).Layer SPF over the top.

Common questions.

What does this replace in my routine?
Your serum, moisturizer, and other active serum products in your routine, such as retinol, peptide serums, niacinamide serums etc. Your cleanser stays. Your sunscreen stays (in the morning). Most of our users drop 2–3 products from their nighttime routine within the first month.
When will I see results?
Most users notice visible improvements, such as smoother texture, improved radiance, within 2 weeks of use. Firmer skin and reduced fine lines typically follow by week 6.
Can I use it with retinol or vitamin C?
Yes. While you wouldn't need Retinol at the same time (since L-01™ produces similar pathway effects), it will not be harmful. Using Vitamin C in the daytime supplements antioxidant effect.
Is it safe for sensitive skin?
Yes, Longevity Protocol is formulated to be soothing and reparative, and tested to be free of irritants, harsh alcohols, allergens, and eczema triggers.
What growth factors are used in L-01™ and how do they benefit the skin?
EGF, FGF-2, and IGF-1. Together they make up a biologically accurate profile of what stem cells secrete to stimulate collagen and elastin production, alongside fibroblast proliferation. This results in visibly firmer, thicker, more resilient skin that has capacity to repair itself against intrinsic and extrinsic damage.
At what age should I start using Longevity Protocol?
Ideally in your mid-20s, but Longevity Protocol is beneficial to all age groups in supporting existing damage repair and preventing further visible aging.
  • 5 stars: 80 (87%)
  • 4 stars: 11 (12%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 1 (1%)
V
Vanessa M

Light lotion like skin moisturizer. Theres no scent and good with sensitive skin.
I’ve noticed a light difference in aiding with glass like skin for fine lines around mouth and forehead.

J
James C.

LOVING the texture of this!!! I've been using for 2 weeks and my skin feels smoother, and my smile lines look less prominent. my foundation used to always cake around the mouth area but the moisturizer really helps with that problem. recommend 10/10 and will be repurchasing.

A
Amie

fantastic! Bought for my sister and I. we're both in our 50s and looking for something that will hold us in between botox and other in-clinic treatments. I've tried many medical grade serums, retinol, and other growth factors in the last few years but glad I added this into my routine! So far feeling my skin is bouncier, has great hydration throughout the day, and my lines look better than couple of weeks ago. This is noticeble in photos which is super impressive after ~3 weeks of consistent use!

M
Mina K.
glow with zero makeup

This is my skin bare, no makeup! Ive had friends ask me what treatment Ive been doing lately, and the answer is nothing new other than this moisturizer! After about two months on the Longevity Protocol my tone is so much more even and there is this natural glow I never used to have. Hydrated, smooth, and my pores look smaller. One step morning and night and I am done.

M
Maya L.
I thought my lines were permanent

I used to think I was already getting these permanent lines around my mouth, nasolabial folds, but it turns out my skin was very dehydrated and inflammed. This product is a godsend for me. It calmed down the inflammation and also properly gave my skin some much needed hydration, and the lines look so much softer. My skin tone has also improved so much, that I realy wear foundation anymore. I've been recommending this to everyone I know.

A
Anonymous

A New Staple in My Skincare Routine

I've tried a lot of moisturizers over the years, but Darkfin Labs has quickly become one of my favorites. The texture is lightweight yet deeply hydrating, sinking into skin without leaving any greasy residue behind.

What really stands out is the serum-like quality of the formula — after applying, my face feels incredibly smooth to the touch, almost like it's been polished. Within minutes, my skin takes on this soft, silky glow that makes it look genuinely nourished rather than just "moisturized." It's the kind of finish that makes you want to keep touching your own face (in a good way!).

I've noticed my skin looks plumper and more radiant with consistent use, and any rough or dry patches have smoothed right out. A little goes a long way, and it layers beautifully under makeup or sunscreen without pilling.

Beyond the product itself, I also had a great experience with customer support. I ran into an issue with my order, and Jason went above and beyond to sort it out quickly and courteously. It's always reassuring when a brand backs up a great product with great service.

If you're looking for a moisturizer that delivers that silky, lit-from-within look — and a company that actually takes care of its customers — I'd highly recommend giving Darkfin Labs a try.

A
Anonymous

This serum is amazing. 3 pumps is definitely enough to use for the face. It absorbs nicely and leaves my face feeling nourished. Will definitely buy more the future

M
Maureen Studniarz

I am only a week in but so far- I really like the product. It’s really nice to have so much in one product and I like that I can use it with tretonin- I am 51, so I am doing all I can (within reason) to keep my skin in good health. I am hoping I can keep my bathroom counter less cluttered- but plan to keep using the serum.

C
Casey

The packaging is defective. I went to use the product and was suprised that after pumping for a while nothing was coming out. Thats becasue there wasnt anything internally to connect to the outside pump to get the product out. Im having to dump it into my hand. Overall, not impressed.

Hi Casey, The packaging is actually supposed to have no straw/connector! its airless do it works via a bottle pump up. It does take a few primes, and we're sorry to hear you experience. Happy to process a full refund.

D
Dalaney Flies

I’m obsessed with the Longevity Protocol. Not only does it simplify my routine, my skin texture has improved significantly as well as its ability to heal. I’m an acne prone girlie and this helped clear up my skin and reduce the discoloration. I took a chance and did the subscription. About a week before my next one would ship, I let my husband try. Little did I know he kept using it—I ran out quicker and had to order more STAT and add an extra one for him. I don’t want to ever run out again!

C
Cynthia

So far, makes my skin look great!

T
Tamara Oliver

It’s perfect—Don’t change a thing! I love this serum/moisturizer combo. I am six weeks in and I can tell it delivers on its promises of bouncier, more radiant skin with better texture and smaller pores. My skin feels balanced and I love the simplicity of this routine. 12/10 no notes!

K
Katie Parnell

Phenomenal product and will be a forever item in my routine!

V
Victoria Corderi Keane

I love the idea of reducing number of products, but I’ve been using less than a week, so too early to render judgment—-really hope it works!

A
Anonymous

Leaves my skin feeling moisturized and shiny. So far so good. I have been using it for the last month!

A
Amie

I'm so impressed by how my skin looks after around a month of daily use. My past main concerns were smile lines, and dehydrated forehead lines. The moisturizer has done a great job of easing them, and makes my skin feel bouncier, and firmer. I'm back for another bottle, this has been a total game changer.

A
Alicia Kuang

Great! Convenient, haven’t seen super noticeable improvements in my skin but no breakouts. Skin looks great too. One thing is that the pump function on mine seems to malfunction a bit. I got it to work after many pumps, but sometimes a weird sound occurs.

K
Kristina Grimm

So far so good on this product. Very expensive and hoping it works. So far I haven't seen any major results in 3 weeks of use. Will update after a few months

T
Tyiesha Green

I’ve recently started using Longevity Protocol and my initial impression has been positive. The formula feels lightweight, absorbs well, and leaves my skin feeling hydrated without feeling greasy. I appreciate the combination of moisturizing and serum benefits in a single product, as well as the thoughtful ingredient profile. I’m looking forward to incorporating it into my daily routine and seeing the long-term results.

R
Renee Stephens

It feels great on my face and is working very nicely

V
Vanessa M

This serum is lightweight on your skin allowing the skin to breathe and easy to apply. There is no scent and leaves skin feeling moisturized. The serums container is in a pretty sturdy and sizable bottle allowing for the product to pump out with ease and may last approximately 3+ months of usage if using day and night. It mixes well with other skin care products. Nice product and look forward to long-lasting glass like skin.

A
Anna D

This is a very beautiful serum. makes my skin feel refreshed, and gives a healthy glow. 10.10

S
Sophia H

Game changer product—I have very sensitive skin prone to peeling, dryness. Also lots of freckles and sun spots. This product that’s really been a godsend for me. I also love how simple it is. Literally I wash my face, put on a few pumps, and bam I’m done no other complicated layers. I’m seeing a lot of texture improvement already and my smile lines are better.

M
Margot J

I'm a new mom so balancing work, a baby, and other stuff has really stressed out my skin. I went from generally good skin (rarely ever needed makeup, no breakouts) in my 30s to looking exhausted and older almost overnight. I've tried a lot of other stuff but this is really amazing! I love how its not greasy AT ALL but still keeps my skin feeling nice and hydrated all day. Ive been noticing a real improvement in the lines around my eyes and forehead. My dark spots are looking brighter after a month of using this stuff. I bought another bottle for hubby to also try. Love seeing new brands innovate and create magic!

E
Elias V.
minimal routine, max results

Guy here who travels a lot and is on planes 24/7, this is exactly what I needed. This is the only thing I use besides sunscreen and my skin has never looked better — smoother, glowy, and just great. I'm very into the sceince as well and their backstory is very impressive, as a biotech lab that started a skincare line. Im all for it and excited to see them make other products down the line.

P
Pia P.
everything you want to know

Writing the detailed version since the short reviews didn't tell me what I wanted before buying. I'm 36, oily T-zone, dry cheeks, and easily broken out. The Longevity Protocol is one of the few things that respects both halves of my face: it hydrates the dry parts without making my forehead an oil slick, and I have not had a single congestion bump in six weeks. The finish is dewy but never greasy, it sits perfectly under sunscreen and makeup with zero pilling, and there's no fragrance to irritate me. Results-wise, my skin tone is more even and my pores look smaller, which I didn't even buy it for. It also collapsed my routine from five products to basically this and SPF, which is the real reason I'll keep buying it.

E
Eloise O.
derm approved

My dermatologist told me to simplify my routine and this was the perfect two-in-one swap. My barrier is happier.

C
Carmen O.
not blown away

It's fine. Hydrating and absorbs well and no irritation, but I'm not seeing the dramatic firming everyone mentions. Decent for the money, maybe.

The longevity protocol

One bottle.
Built for the next 60 years.

$74 subscribe · $93 one-time · free US shipping · 45-day money back