First Aging Driver: Stem Cell Exhaustion
By 25, skin enters its early aging phase (pre-aging). This is a key intervention window to begin optimizing skin state.
Stem cells, which control repair and release key regenerative signals, begin to slow and slip into senescence. As their signaling drops, communication between skin cells breaks down.
This leads to slower cell renewal, increased inflammation, reduced collagen and elastin production, and manifests in visible signs of aging such as fine lines, pigmentation, laxity, and skin thinning. This drives "rapid aging" appearance in a matter of a few years.
Skin aging happens at the cellular level. So does our testing.
In-vitro, 3% concentration, third-party tested
The Invention that started it all: Engineered Stem Cell (ESC)
Our founder developed and patented the world's first synthetic stem cells — replicating the regenerative signals healthy cells produce and encapsulating them in biomimetic "cell membranes" for precision delivery.
The core insight: aging skin doesn't lose its ability to repair. It loses the signals that tell it to.
That discovery drove a decade of research into what those signals are, which ones matter most, and how to deliver them intact to the cells that need them. The result is a precision delivery platform purpose-built for regenerative protein cargo, the foundation we built everything on.
L-01™: The Breakthrough Longevity Complex
Built on the same delivery platform, L-01™ is a complex of 100% plant-derived, human-identical signaling proteins — precision-engineered to restore what your skin stops producing on its own.
Every factor in L-01™ was selected through thousands of AI-enabled screens, testing combinations for synergistic activity across the key pathways of skin aging. It is a coordinated signal system designed to repair and regenerate at the cellular level.
Epidermal Growth Factor is a naturally occurring polypeptide with 53 amino acids
The most studied skin cell activator. Key activator of fibroblasts to produce collagen and elastin, accelerating damage repair and cell regeneration. Most EGF can't penetrate the top layer of skin to work underneath. L-01™ contains EGF with a proprietary delivery system to ensure optimal bioavailability.
Fibroblast Growth Factor-2, also known as basic FGF
Promotes fibroblast proliferation, collagen synthesis, and angiogenesis (formation of new blood vessels). In the skin, it accelerates wound healing, enhances dermal regeneration, and helps restore firmness and elasticity by supporting both structural proteins and vascular supply.
Insulin Growth Factor-1
helps modulate inflammation in the skin by promoting cellular repair and reducing pro-inflammatory signaling. It counteracts the effects of inflammatory cytokines that degrade collagen and accelerate aging. By supporting balanced fibroblast and keratinocyte activity, IGF-1 maintains tissue integrity and prevents chronic inflammation that leads to skin thinning and loss of elasticity.
Nicotinamide Adenine Dinucleotide precursor
NAD+ is difficult to absorb by itself. Our approach boosts NAD+ levels by enhancing the expression of the rate-limiting enzyme NAMPT, so the body produces more NAD+ naturally. This works together with the above signal proteins to help maintain skin health and repair. Ingredient is derived from sunflower biosynthesis.
L-01™ vs. Retinol
The Result
Stimulates Cellular Metabolism
Enhances mitochondrial energy production and accelerates cell renewal.
Reduces Inflammation
Modulates inflammatory pathways to support skin health, reduce pigmentation, and balanced healing.
Supports Collagen Synthesis
Activates fibroblasts to increase collagen and elastin production, improving firmness and texture.
Enhances Endogenous Repair
Strengthens the skin’s natural repair capacity by promoting protein synthesis and tissue regeneration.
Reverse your skin's biological age now.
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Research That Shapes Us
ECM degradation is one of the primary structural drivers of visible aging. L-01™ targets this directly by activating fibroblasts to rebuild collagen and restore the skin's structural foundation.
Growth factors degrade before reaching target cells without the right delivery system. L-01™ uses encapsulation technology to protect its actives and ensure bioavailability.
Skin aging has multiple drivers — biological(internal) and environmental(external). L-01™'s four-module system(Repair, Reactivate, Rebuild, and Protect) was designed to address both, not just surface symptoms.
Combining multiple growth factors addresses aging more effectively than any single active. This is why L-01™ delivers EGF, FGF-2, and IGF-1 together as a synchronized complex.
EGF and FGF overcome TGF-β's inhibitory effect on fibroblasts, unlocking collagen production. L-01™ is formulated around this synergy — the combination is what drives the result.