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L-01™ LONGEVITY PROTOCOL

FACE SERUM + MOISTURIZER

4.8(137)4.8 out of 5 stars, 137 reviews

One step that replaces your serums and moisturizer.

  • SENSITIVE SKIN SAFE
  • LONGEVITY PEPTIDE

Combining the benefits of 5 skincare steps into 1 streamlined formula, Longevity Protocol strategically delivers biotech actives to deeply moisturize, visibly improve fine lines and wrinkles, uneven texture, firmness, and more, for dewy, glass-like skin.

  • Clinically tested
  • Fragrance-free
  • 45-day money-back guarantee

Free shipping

56% improvement in firmness in 1 month1
Recommended by dermatologists
“…well-researched approach to supporting skin barrier function and improving the appearance of visible aging.”
Dr. Jen HaleyBoard-certified Dermatologist
CLINICAL RESULTS. 80+ REAL PEOPLE

VISIBLE RESULTS

Before
Before
After 28 days
After
Eye area, close-up

RESULTS BUILD WITH CONSISTENT USE

2 WEEKS
  • 18.6% reduction in wrinkle depth3
  • 15.5% less moisture loss3
  • 11% reduction in redness1
1 MONTH
  • 25.5% reduction in wrinkle depth3
  • 57% improvement in hydration1
  • 56% improvement in firmness1
3 MONTHS

Foundation built for skin longevity

1 bottle lasts ~3 months. 2-3 pumps AM + PM daily.

STEM CELL SIGNALING PEPTIDES

POWERED BY L-01™

3.1% L-01™ COMPLEX IN EVERY PUMP
READ THE SCIENCE
WHAT IT IS

Plant-grown growth factors (EGF, FGF-2, IGF-1), identical to the ones your skin makes. Plus NAD+ support. Novel longevity breakthrough.

HOW IT WORKS

Works across 3 key hallmarks of skin aging at once: collagen, inflammation and senescence.

WHO IT’S FOR

Skin that shows fine lines, dullness or a weak barrier. Or, visible signs of aging. Safe for sensitive skin.

READ THE SCIENCE

Full ingredient list under Key ingredients below.

on real skin

SEE IT IN REAL LIFE

Model applying the serum
because you're busy...us too

ONE STEP. AM + PM.

  1. 01Cleanse. Start with clean, dry skin.
  2. 02Apply. 2–3 pumps over face and neck.
  3. 03SPF. In the morning, layer SPF on top.
PAIRS WITH
L-00 Cleanser first. SPF on top in the morning. Retinoid (optional) at night.
WHAT’S INSIDE

KEY INGREDIENTS

Precision Repair + Defense Biosystem
L-01™
L-01™

Proprietary complex made of encapsulated EGF, FGF-2, and IGF-1 alongside powerful NAD+ precursor complex. It mimics young skin's natural signaling peptides for repair and enhanced skin vitality.

QUESTIONS

Is it safe for sensitive skin?

Yes, Longevity Protocol is formulated to be soothing and reparative, and tested to be free of irritants, harsh alcohols, allergens, and eczema triggers.

When will I see results?

Most users notice visible improvements, such as smoother texture, improved radiance, within 2 weeks of use. Firmer skin and reduced fine lines typically follow by week 6.

Can I use it with retinol, vitamin C or acids?

Yes. While you wouldn't need Retinol at the same time (since L-01™ produces similar pathway effects), it will not be harmful. Using Vitamin C in the daytime supplements antioxidant effect. Don’t layer strong exfoliating acids in the same step.

What does it replace?

Your serum, moisturizer, and other active serum products in your routine, such as retinol, peptide serums, niacinamide serums etc. Your cleanser stays. Your sunscreen stays (in the morning). Most of our users drop 2–3 products from their nighttime routine within the first month.

How long does a bottle last?

1 bottle lasts ~3 months. 2-3 pumps AM + PM daily.

Is there a money-back guarantee?

Yes. Every order comes with a 45-day money-back guarantee. If you’re not satisfied with the product, return it within 45 days for a full refund.

How does the subscription work?

Delivered every 90 days. 20% off every order. Skip or cancel anytime.

SHIPPING & GUARANTEE

Free shipping on orders $50+.

45-day money-back guarantee: if you’re not satisfied with the product, return it for a full refund.

Shipping policy · Refund policy

REVIEWS

  • 5 stars: 115 (84%)
  • 4 stars: 20 (15%)
  • 3 stars: 0 (0%)
  • 2 stars: 1 (1%)
  • 1 star: 1 (1%)
V
Vanessa M

Light lotion like skin moisturizer. Theres no scent and good with sensitive skin.
I’ve noticed a light difference in aiding with glass like skin for fine lines around mouth and forehead.

S
Steven Reddy

The positives are (1) I love the minimal and intentional packaging, and (2) I love the feel of the product on my skin. The negatives are (1) the product smells like damp cardboard, and (2) the cannister would benefit from a light knurl texture to increase gripping when hands are damp (like after showering). Overall, I'm unsure if The L01 protocol is working; I've been using it twice a day, everyday for two weeks and I haven't noticed a difference in the tone or texture of my skin. I doubt I'm the target audience as I'm already an avid user of moisturizer and toner and do my best to protect my skin from excess sun exposure. I'll keep using it to support Anna and her efforts! Looking forward to the next set of products!

- Steven

J
James C.

LOVING the texture of this!!! I've been using for 2 weeks and my skin feels smoother, and my smile lines look less prominent. my foundation used to always cake around the mouth area but the moisturizer really helps with that problem. recommend 10/10 and will be repurchasing.

A
Amie

fantastic! Bought for my sister and I. we're both in our 50s and looking for something that will hold us in between botox and other in-clinic treatments. I've tried many medical grade serums, retinol, and other growth factors in the last few years but glad I added this into my routine! So far feeling my skin is bouncier, has great hydration throughout the day, and my lines look better than couple of weeks ago. This is noticeble in photos which is super impressive after ~3 weeks of consistent use!

M
Mina K.
glow with zero makeup

This is my skin bare, no makeup! Ive had friends ask me what treatment Ive been doing lately, and the answer is nothing new other than this moisturizer! After about two months on the Longevity Protocol my tone is so much more even and there is this natural glow I never used to have. Hydrated, smooth, and my pores look smaller. One step morning and night and I am done.

M
Maya L.
I thought my lines were permanent

I used to think I was already getting these permanent lines around my mouth, nasolabial folds, but it turns out my skin was very dehydrated and inflammed. This product is a godsend for me. It calmed down the inflammation and also properly gave my skin some much needed hydration, and the lines look so much softer. My skin tone has also improved so much, that I realy wear foundation anymore. I've been recommending this to everyone I know.

A
Anonymous

A New Staple in My Skincare Routine

I've tried a lot of moisturizers over the years, but Darkfin Labs has quickly become one of my favorites. The texture is lightweight yet deeply hydrating, sinking into skin without leaving any greasy residue behind.

What really stands out is the serum-like quality of the formula — after applying, my face feels incredibly smooth to the touch, almost like it's been polished. Within minutes, my skin takes on this soft, silky glow that makes it look genuinely nourished rather than just "moisturized." It's the kind of finish that makes you want to keep touching your own face (in a good way!).

I've noticed my skin looks plumper and more radiant with consistent use, and any rough or dry patches have smoothed right out. A little goes a long way, and it layers beautifully under makeup or sunscreen without pilling.

Beyond the product itself, I also had a great experience with customer support. I ran into an issue with my order, and Jason went above and beyond to sort it out quickly and courteously. It's always reassuring when a brand backs up a great product with great service.

If you're looking for a moisturizer that delivers that silky, lit-from-within look — and a company that actually takes care of its customers — I'd highly recommend giving Darkfin Labs a try.

S
Suraya L
great under makeup

I like layering thi sunder sunscreen and makeup. Helps it go on smoother.

E
Emily D.
Beautiful packaging, even better formula

Looks gorgeous on my vanity and the formula delivers. Silky, absorbs in seconds, skin feels soft all day.

A
Anonymous

This serum is amazing. 3 pumps is definitely enough to use for the face. It absorbs nicely and leaves my face feeling nourished. Will definitely buy more the future

P
Priya S.
Love the science behind it

I read every ingredient list and this one actually made sense to me. Feels luxurious, no fragrance overload, and my skin looks brighter in the morning.

R
Rachel M.
Finally a routine I stick to

One step, morning and night, and I'm done. My skin feels plump and hydrated all day and my makeup sits so much better. Three weeks in and I'm not going back.

M
Maureen Studniarz

I am only a week in but so far- I really like the product. It’s really nice to have so much in one product and I like that I can use it with tretonin- I am 51, so I am doing all I can (within reason) to keep my skin in good health. I am hoping I can keep my bathroom counter less cluttered- but plan to keep using the serum.

j
jennifer
Love this serum

I started using this recently and wow! I'm a fan. Its made my daily routine soo much easier.

B
Brooke M.
Almost perfect

Great hydration and a nice texture. On very dry winter days I add a little extra moisturizer on top, but otherwise it's all I need.

C
Casey

The packaging is defective. I went to use the product and was suprised that after pumping for a while nothing was coming out. Thats becasue there wasnt anything internally to connect to the outside pump to get the product out. Im having to dump it into my hand. Overall, not impressed.

Hi Casey, The packaging is actually supposed to have no straw/connector! its airless do it works via a bottle pump up. It does take a few primes, and we're sorry to hear you experience. Happy to process a full refund.

K
Kelly R.
Impressed so far

One month in and I'm happy. Skin feels softer and looks brighter. Docking one star only because shipping took a bit longer than expected.

D
Dalaney Flies

I’m obsessed with the Longevity Protocol. Not only does it simplify my routine, my skin texture has improved significantly as well as its ability to heal. I’m an acne prone girlie and this helped clear up my skin and reduce the discoloration. I took a chance and did the subscription. About a week before my next one would ship, I let my husband try. Little did I know he kept using it—I ran out quicker and had to order more STAT and add an extra one for him. I don’t want to ever run out again!

N
Natalie E.
My go-to for travel

Since it's an all-in-one, it's the only skincare I pack now. Skin stays happy even on long flights.

K
Karen W.
Simple and effective

I'm 52 and have tried everything. This is the first product where I can see a real difference in how firm and bouncy my skin looks. Simple routine, great results.

J
Jessica Marker
good with retinol

it pairs well with my other retinol product, and my skin feels good after (no irritation)

H
Hannah B.
Hydration that lasts

I live in Denver and my skin is always dry. This keeps me hydrated well into the evening. Huge win.

O
Olivia C.
Gentle on sensitive skin

I have rosacea-prone skin and was nervous, but no redness or stinging at all. It feels calming and comfortable.

C
Cynthia

So far, makes my skin look great!

T
Tara Q.
Visible glow

Friends keep asking if I've been on vacation. It's this. My skin just looks lit from within.

T
Tamara Oliver

It’s perfect—Don’t change a thing! I love this serum/moisturizer combo. I am six weeks in and I can tell it delivers on its promises of bouncier, more radiant skin with better texture and smaller pores. My skin feels balanced and I love the simplicity of this routine. 12/10 no notes!

M
Megan T.
Glow without the grease

I have combination skin and most moisturizers break me out or leave me shiny. This one just leaves a soft glow. Obsessed.

K
Katie Parnell

Phenomenal product and will be a forever item in my routine!

ONE BOTTLE. BUILT FOR THE NEXT 60 YEARS